Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening.

Establishment of a reliable in vitro liver models for drug screening remnants challenge with respect to the withdrawal of hepatocyte spheroids growth and adapt to the current high-throughput systems. In this study, short fibers used as a scaffold for the generation of controlled size hepatocyte spheroids that recapitulate in vivo phenotype and function of the heart. Spheroid formation is modulated by the length and galactose / RGD graft of short fibers, and fibers of short length 50 m motivating the formation of spherical with optimal liver function. short fibers distributed throughout the entire round for the withdrawal of hepatocyte growth compact to form spheroids.

Compared to free scaffolding spheroid culture in agarose-coated plates, culture round with short fibers achieve higher clearance level of the drug model and provide a better prediction of in vivo drug clearance rate with 0.886 correlation value.

In addition, the ability of drug metabolism is very sensitive to metabolic enzyme inducers and inhibitors, and responsiveness was maintained for 20 days of culture, showed efficient in vitro models to determine drug-drug interactions. Therefore, cultural round with short fibers provide strategies easily manipulated to maintain hepatocyte function for a long period and allowing ready to be placed in a conventional multiwell plates and a variety of tools organ-on-a-chip for high-throughput drug screening.

Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening.
Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening.

3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improved Human hepatocytes (C3A) Function and Polarity.

3D in vitro hepatocyte culture is a core aspect of liver tissue engineering. However, the conventional 3D culture can not maintain hepatocyte polarity, functional phenotype, or survival. Here, we employ a microfluidic chip technology combined with naturally alginate hydrogel to build a 3D liver tissue mimicking liver dish.

We comprehensively evaluated the survival of cultured hepatocytes, functions, and polarity. transcriptome sequencing was used to analyze changes in hepatocyte polarity pathway. The data show that, with increasing duration of the culture, the viability, function, polarity, mRNA expression, and ultrastructure of liver hepatocytes plate mimetic enhanced 3D.

Furthermore, liver dishes 3D mimetic culture can promote changes in bile secretion pathway through effector mechanisms associated with nuclear receptors, bile uptake and efflux transporters. This study provides a scientific basis and evidence for the physiological structure of the bionic hearts prepared using 3D culture.

Primary Rat (Wistar Han) Hepatocytes, Plateable

T0106 5x10^5 cells / 1.0 ml
EUR 1375

Rat Sprague Dawley Serum

IRTSDSER1000ML each
EUR 848
Description: Rat Sprague Dawley Serum

Rat Sprague Dawley Serum

IRTSDSER100ML each
EUR 187
Description: Rat Sprague Dawley Serum

Rat Sprague Dawley Serum

IRTSDSER10ML each
EUR 59
Description: Rat Sprague Dawley Serum

Rat Sprague Dawley Serum

IRTSDSER500ML each
EUR 481
Description: Rat Sprague Dawley Serum

Rat Sprague Dawley Serum

IRTSDSER50ML each
EUR 102
Description: Rat Sprague Dawley Serum

Primary Rat (Wistar Han) Hepatocytes, Suspension

T0105 5x10^5 cells / 1.0 ml
EUR 1375

Rat Sprague Dawley Plasma

IRTSDPLAK2E1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK2E100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK2E10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK2E500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK2E50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK3E1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK3E100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK3E10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK3E500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLAK3E50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLALIH1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLALIH100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLALIH10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLALIH500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLALIH50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAC1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAC100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAC10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAC500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAC50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAE1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAE100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAE10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAE500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAE50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAH1000ML each
EUR 848
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAH100ML each
EUR 187
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAH10ML each
EUR 59
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAH500ML each
EUR 481
Description: Rat Sprague Dawley Plasma

Rat Sprague Dawley Plasma

IRTSDPLANAH50ML each
EUR 102
Description: Rat Sprague Dawley Plasma

*Rat Sprague Dawley Albumin

IRTSDALB100MG each
EUR 229
Description: *Rat Sprague Dawley Albumin

*Rat Sprague Dawley Albumin

IRTSDALB200MG each
EUR 401
Description: *Rat Sprague Dawley Albumin

Primary Dog (Beagle) Hepatocytes, Plateable

T0118 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Suspension

T0117 5x10^5 cells / 1.0 ml
EUR 1375

Normal Human Primary Plateable Hepatocytes

T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes

T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes

T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Rat Sprague Dawley Red Blood Cells

IRTSDRBC100ML each
EUR 443
Description: Rat Sprague Dawley Red Blood Cells

Rat Sprague Dawley Red Blood Cells

IRTSDRBC10ML each
EUR 118
Description: Rat Sprague Dawley Red Blood Cells

Rat Sprague Dawley Red Blood Cells

IRTSDRBC25ML each
EUR 220
Description: Rat Sprague Dawley Red Blood Cells

Rat Sprague Dawley Red Blood Cells

IRTSDRBC50ML each
EUR 309
Description: Rat Sprague Dawley Red Blood Cells

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) hepatocytes, Plateable

T0112 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million

T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

*Rat Sprague Dawley IgG Affinity Purified

IRTSDIGGAP1000MG each
EUR 965
Description: *Rat Sprague Dawley IgG Affinity Purified

*Rat Sprague Dawley IgG Affinity Purified

IRTSDIGGAP10MG each
EUR 117
Description: *Rat Sprague Dawley IgG Affinity Purified

*Rat Sprague Dawley IgG Affinity Purified

IRTSDIGGAP50MG each
EUR 168
Description: *Rat Sprague Dawley IgG Affinity Purified

Rat Sprague Dawley IgG Fractionated Purified

IRTSDIGGGF500MG each
EUR 607
Description: Rat Sprague Dawley IgG Fractionated Purified

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Innovative Grade US Origin Rat Sprague Dawley Lung

IGRTSDLG each
EUR 30
Description: Innovative Grade US Origin Rat Sprague Dawley Lung

Innovative Grade US Origin Rat Sprague Dawley Brain

IGRTSDBR each
EUR 30
Description: Innovative Grade US Origin Rat Sprague Dawley Brain

Innovative Grade US Origin Rat Sprague Dawley Heart

IGRTSDHT each
EUR 30
Description: Innovative Grade US Origin Rat Sprague Dawley Heart

Innovative Grade US Origin Rat Sprague Dawley Liver

IGRTSDLR each
EUR 30
Description: Innovative Grade US Origin Rat Sprague Dawley Liver

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Serum

IGRTSDSER50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Serum

Innovative Grade US Origin Rat Sprague Dawley Kidney

IGRTSDKD each
EUR 30
Description: Innovative Grade US Origin Rat Sprague Dawley Kidney

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK2E50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLAK3E50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLALIH50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAC50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAE50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH1000ML each
EUR 5440
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH100ML each
EUR 612
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH10ML each
EUR 113
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH25ML each
EUR 171
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH500ML each
EUR 2891
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Innovative Grade US Origin Rat Sprague Dawley Plasma

IGRTSDPLANAH50ML each
EUR 324
Description: Innovative Grade US Origin Rat Sprague Dawley Plasma

Rat Sprague Dawley IgG Fractionated Purified Lyophilized

IRTSDIGGGFLY1000MG each
EUR 1080
Description: Rat Sprague Dawley IgG Fractionated Purified Lyophilized

Rat Sprague Dawley IgG Fractionated Purified Lyophilized

IRTSDIGGGFLY100MG each
EUR 662
Description: Rat Sprague Dawley IgG Fractionated Purified Lyophilized

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK2E100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK2E10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK2E25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK2E50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK3E100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK3E10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK3E25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBK3E50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBLIH100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBLIH10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBLIH25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBLIH50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAC100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAC10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAC25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAC50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAE100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAE10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAE25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAE50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAH100ML each
EUR 544
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAH10ML each
EUR 125
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAH25ML each
EUR 242
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Whole Blood

IGRTSDWBNAH50ML each
EUR 307
Description: Innovative Grade US Origin Rat Sprague Dawley Whole Blood

Innovative Grade US Origin Rat Sprague Dawley Complement Serum

IGRTSDCSER10ML each
EUR 142
Description: Innovative Grade US Origin Rat Sprague Dawley Complement Serum

Innovative Grade US Origin Rat Sprague Dawley Complement Serum

IGRTSDCSER25ML each
EUR 286
Description: Innovative Grade US Origin Rat Sprague Dawley Complement Serum

Innovative Grade US Origin Rat Sprague Dawley Complement Serum

IGRTSDCSER50ML each
EUR 456
Description: Innovative Grade US Origin Rat Sprague Dawley Complement Serum

Innovative Grade US Origin Rat Sprague Dawley Complement Serum

IGRTSDCSER5ML each
EUR 89
Description: Innovative Grade US Origin Rat Sprague Dawley Complement Serum

*Innovative Grade US Origin Rat Sprague Dawley Brain Lyophilized

IRTSDBRLY1000MG each
EUR 100
Description: *Innovative Grade US Origin Rat Sprague Dawley Brain Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Brain Lyophilized

IRTSDBRLY2000MG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Brain Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Liver Lyophilized

IRTSDLRLY1000MG each
EUR 100
Description: *Innovative Grade US Origin Rat Sprague Dawley Liver Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Liver Lyophilized

IRTSDLRLY2000MG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Liver Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Kidney Lyophilized

IRTSDKDLY1000MG each
EUR 100
Description: *Innovative Grade US Origin Rat Sprague Dawley Kidney Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Kidney Lyophilized

IRTSDKDLY2000MG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Kidney Lyophilized

*Innovative Grade US Origin Rat Sprague Dawley Lung Tissue Lysate

IRTSDLGTL200UG each
EUR 105
Description: *Innovative Grade US Origin Rat Sprague Dawley Lung Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Lung Tissue Lysate

IRTSDLGTL400UG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Lung Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Brain Tissue Lysate

IRTSDBRTL200UG each
EUR 105
Description: *Innovative Grade US Origin Rat Sprague Dawley Brain Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Brain Tissue Lysate

IRTSDBRTL400UG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Brain Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Heart Tissue Lysate

IRTSDHTTL200UG each
EUR 105
Description: *Innovative Grade US Origin Rat Sprague Dawley Heart Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Heart Tissue Lysate

IRTSDHTTL400UG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Heart Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Liver Tissue Lysate

IRTSDLRTL200UG each
EUR 105
Description: *Innovative Grade US Origin Rat Sprague Dawley Liver Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Liver Tissue Lysate

IRTSDLRTL400UG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Liver Tissue Lysate

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASK2EVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASK3EVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASLIHVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASNACVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASNAEVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

IGRTSDPLASNAHVIAL each
EUR 86
Description: Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma

*Innovative Grade US Origin Rat Sprague Dawley Kidney Tissue Lysate

IRTSDKDTL200UG each
EUR 105
Description: *Innovative Grade US Origin Rat Sprague Dawley Kidney Tissue Lysate

*Innovative Grade US Origin Rat Sprague Dawley Kidney Tissue Lysate

IRTSDKDTL400UG each
EUR 165
Description: *Innovative Grade US Origin Rat Sprague Dawley Kidney Tissue Lysate

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium

9-25095 5 x 100 ml Ask for price

Rat Hepatocytes

ABC-TC4136 1 vial Ask for price
Description: Rat Hepatocytes (RH) are isolated from adult rat livers. They are cryopreserved at the end of primary cell isolation.

Rat Plateable Hepatocytes

ABC-TC4024 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat

4-20302 ea Ask for price

Human Hepatocytes

HC4230 500,000 Cells
EUR 991.2

Human Hepatocytes

ABC-TC3646 1 vial Ask for price
Description: The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell transplantation and clinical liver support systems. In appropriate culture condition, cultured human hepatocytes proliferate and maintain differentiated hepatocyte function such as the synthesis of serum proteins. HH from Gentaur Research Laboratories are isolated from human liver. HH are cryopreserved immediately after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HH are characterized by immunofluorescent method with antibodies to albumin, cytokeratin-18 and vimentin. HH are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HH is not recommended for expanding or long term cultures since the cells do not proliferate in culture.

Mouse Hepatocytes

ABC-TC3928 1 vial Ask for price
Description: Our High Quality Mouse Hepatocytes have been isolated from mouse livers after liver perfusion and low-speed differential centrifugation. The hepatocytes are cryoperserved immediately after the experimental process and delivered frozen.

Immortalized Rat Hepatocytes - SV40

T0078 1x106 cells / 1.0 ml Ask for price

Bovine Hepatocytes

ABC-TC3132 1 vial Ask for price
Description: Bovine hepatocytes, 4-week bovine

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
Description: Rat Hepatocytes Suspension - Adult

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Rabbit Liver Hepatocytes

ABC-TC4061 1 vial Ask for price
Description: Rabbit liver epithelial cells, 5-week rabbit

Plateable Mouse Hepatocytes

ABC-TC4023 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Immortalized human hepatocytes

ABI-TC3500 1 vial Ask for price
Description: The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.

Plateable DOG (Beagle) Hepatocytes

ABC-TC4021 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

System and liver tissue cultured described here can serve as a better in vitro Platform culture of 3D and basic unit for varied applications, including drug development, research hepatocyte polarity, the design of the bioreactor liver bioartificial, and network and construction of organs for tissue engineering heart or liver cholestasis injury.