Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.

CYP3A4 induction is an important cause of drug-drug interactions, making early identification of drug candidates with the obligations CYP3A4 induction in drug development prerequisites. Here, we present a 3D spheroid cultures of primary human hepatocytes (PHH) as CYP3A4 induction of new screening models.

Screening of 25 drugs (12 known inducers of CYP3A4 in vivo and 13 negative control) at physiologically relevant concentrations revealed 100% sensitivity and 100% specificity system. Three of inducers of CYP3A4 in vivo induction of CYP3A4 displayed capacity is much higher in comparison with the 3D spherical culture in 2D monolayer culture. Among them, we identify AZD1208, PIM kinase inhibitor in Phase I development stopped because of unexpected autoinduction CYP3A4, CYP3A4 inducer as the only active in 3D spheroids but not in 2D monolayer culture.

Gene knockdown experiments revealed that AZD1208 require PXR to induce CYP3A4. Rifampicin require PXR solely to induce CYP3A4 and CYP2B6, while phenobarbital-mediated induction of CYPs is not indicative of the absolute dependence on both PXR or CAR demonstrated its ability to switch the activation of nuclear receptors. Mechanistic Study of AZD1208 to find involvement of MAPK / ERK pathway in induction of CYP3A4-sensitive culture format used, as revealed by the inhibition of ERK1 / 2 phosphorylation Tyr204 and sensitivity to EGF pressure. Accordingly, we also identified lapatinib, a dual EGFR / HER2 inhibitor, such as CYP3A4 inducer active just another round in 3D culture.

Our findings offer insight into the pathways involved in the induction of CYP3A4 and suggest spheroids PHH for preclinical screening of CYP3A4 induction.

Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.
Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.

Glucose and lipid metabolism screening models of hepatocyte spheroids after culture by injecting fiber fragments.

With the increase in obesity, diabetes and other metabolic diseases, in vitro liver cell and tissue models play an important role in the identification of active pharmaceutical ingredients. Up to now three-dimensional (3D) models rarely focuses on the culture of hepatic glucose and lipid metabolism.

In addition, primary human liver cells suffer from limited availability and differences among donors to build the model reproduced. Thus, in this study, the most available human liver cancer cells (HepG2), and primary hepatocytes from rat (RPH) proposed to build a 3D spheroids using fiber fragments graft syringe with galactose (GSF) as a substrate. RPH and spheroids showed HepG2 cells and cell fragments strong-fiber interaction to promote cell survival, albumin and urea synthesis.

Compared with HepG2 spheroids, spheroids RPH demonstrate strong abilities in terms of consumption of glucose metabolism of glucose, glycogen intracellular content, the level of glucose in gluconeogenesis and sensitivity to the hormone modulators such as insulin and glucagon. On the other hand, HepG2 spheroids displays a strong ability of lipid metabolism in produce significantly higher levels of total cholesterol and triglycerides.

Compared with those who did not fragment the fiber, the GSF-supported 3D culture establish an effective model for in vitro glucose (RPH spheroids) and lipid metabolism (HepG2 spheroids). The model confirmed screening of each enzyme activity and gene expression and showed significantly higher sensitivity and clinically relevant response to hypoglycemic and lipid-lowering drugs.

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Human Hepatocytes - Alcohol Addicted

HC4230AA 500,000 Cells
EUR 1148.4

Human Hepatocytes - Opioid Addicted

HC4230OP 500000
EUR 1148.4

Immortalized Human Hepatocytes - hTERT

T0058 1x106 cells / 1.0 ml Ask for price

Immortalized Human Hepatocytes - Ras

T0059 1x106 cells / 1.0 ml Ask for price

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes - SV40

T0101 1x106 cells / 1.0 ml Ask for price

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium

9-25095 5 x 100 ml Ask for price

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80322 1 x 100 ml Ask for price

Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol)

RAT-5 1
EUR 1365.6

Primary UTI

MED1270 PK10
EUR 10.99

Immortalized Mouse Hepatocytes-Conditionally (ImHep)

T0099 1x106 cells / 1.0 ml Ask for price

TnI (Primary) Antibody

abx018056-100ug 100 ug
EUR 410.4

Primary Human Neurons

HNC001 300,000 Cyroperserved Cells
EUR 1467.6

Primary UTI Opaque

MED1272 PK10
EUR 11.81

Primary UTI Agar

MED1334 EACH
EUR 573.42

Primary Opalescence Solution

EPPOS01 100ML
EUR 98.04

Human Primary Chondrocytes

171-T0020 5 Cells
EUR 2760

Rat Primary hepatic carcinoma ELISA kit

E02P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Liver Dissociation System 1 (Hepatocytes), Mouse

4-20301 ea Ask for price

Immortalized Hamster Hepatocytes-SV40 T+t

T0071 1x106 cells / 1.0 ml Ask for price

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml Ask for price

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat

4-20306 ea Ask for price

Rat of the Wistar strain, 22 organs, 66 cores (1.5mm), set 1

ART661 1
EUR 300
Description: Normal tissues of 22 major organs triplicated from 3 Wistar strain rats, set 1, non-overlapping with ART662

Rat of the Wistar strain, 22 organs, 66 cores (1.5mm), set 2

ART662 1
EUR 300
Description: Normal tissues of 22 major organs triplicated from 3 Wistar strain rats, set 2, non-overlapping with ART661

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat

4-20303 ea Ask for price

Antigen-Antibody Pen For Rat Primary antibodies

PEN-R10 1
EUR 242.4

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80306 1 x 100 ml Ask for price

Human Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80314 1 x 100 ml Ask for price

DB Primary Antibody diluent

DB-D-125 125 ml
EUR 180

DB Primary Antibody diluent

DB-D-250 250 ml
EUR 294

DB Primary Antibody diluent

DBD-125 125 ml
EUR 180

DB Primary Antibody diluent

DBD-250 250 ml
EUR 294

Primary Antibody Dropper Vial

PAV015 1 ea.
EUR 63.6

Primary Blue Solution 100ml

EPBS01 100ML
EUR 98.04

Primary Red Solution 100ml

EPRS01 100ML
EUR 145.92

Rat Aoc3/ Membrane primary amine oxidase ELISA Kit

E0075Ra 1 Kit
EUR 685.2

Rat Membrane primary amine oxidase(AOC3) ELISA kit

CSB-EL001855RA-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Membrane primary amine oxidase(AOC3) ELISA kit

1-CSB-EL001855RA
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ELISA kit for Rat Membrane primary amine oxidase

EK2706 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

Rat Aoc3(Membrane primary amine oxidase) ELISA Kit

ER0434 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml

Rat Breast PrimaCell: Normal Mammary Epithelial Primary Cells

2-82522 1 Kit Ask for price

Rat Myeloid differentiation primary response protein MyD88, Myd8

ELI-05538r 96 Tests
EUR 1063.2

Primary Antibody Diluent (Phosphate, Green)

APG010 10 L
EUR 805.2

Primary Antibody Diluent (Phosphate, Green)

APG125 125 ml
EUR 88.8

Primary Antibody Diluent (Phosphate, Green)

APG500 500 ml
EUR 121.2

Primary Antibody Diluent (Phosphate, Green)

APG999 1000 ml
EUR 148.8

Primary Antibody Diluent (Tris, Green)

ATG-20000 20 L
EUR 1412.4

Primary Antibody Diluent (Tris, Green)

ATG125 125 ml
EUR 88.8

Primary Antibody Diluent (Tris, Green)

ATG500 500 ml
EUR 121.2

Primary Antibody Diluent (Tris, Green)

ATG999 1000 ml
EUR 148.8

MicroMolar Primary Amine Assay Kit

PAA100K 100 assays
EUR 168.93
Description: This product includes 0.5 ml of 10 x PPA dye, 5.5 ml of Assay buffer, 5 ml of reagent A and 0.05 ml of 1 mM methylamine-HCl. It is for measurement of 100 samples using 96-well plates. Cuvettes may also be used for measurements.

Western blot Kit for Rat Primary Antibodies, Chemilum. Substrate

80203-Rt 1 kit
EUR 781.2

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Human Primary hepatic carcinoma ELISA kit

E01P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Western Blot Primary Antibody Diluent Buffer

abx090689-100ml 100 ml
EUR 218.4

Myeloid Differentiation Primary Response 88 Antibody

20-abx137458
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Membrane Primary Amine Oxidase (AOC3) Antibody

20-abx110946
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Membrane Primary Amine Oxidase (AOC3) Antibody

20-abx001627
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Membrane Primary Amine Oxidase (AOC3) Antibody

abx033988-400ul 400 ul
EUR 627.6

Membrane Primary Amine Oxidase (AOC3) Antibody

abx033988-80l 80 µl
EUR 343.2

Myeloid Differentiation Primary Response 88 Protein

20-abx261025
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Membrane Primary Amine Oxidase (AOC3) Antibody

20-abx333876
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

CP Reagent Coloration Primary Solution Blue

CPPB01 100ML
EUR 111.72

CP Reagent Coloration Primary Solution Red

CPPR01 100ML
EUR 166.44

CP Reagent Coloration Primary Solution Yellow

CPPY01 100ML
EUR 111.72

Rat Myd88/ Myeloid differentiation primary response protein MyD88 ELISA Kit

E0652Ra 1 Kit
EUR 685.2

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit

E02M0411-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit

E02M0411-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit

E02M0411-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Breast PrimaCell: Normal Mammary Epithelial Primary Cells Growth Medium

9-25022 5 x 100 ml Ask for price

Rat Breast Tissue Preparation Buffer: Normal Mammary Epithelial Primary Cells

9-80229 1 x 100 ml Ask for price

Aoc3 ELISA Kit| Rat Membrane primary amine oxidase ELISA Kit

EF017277 96 Tests
EUR 826.8

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Membrane Primary Amine Oxidase (AOC3) Antibody (HRP)

20-abx336489
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Membrane Primary Amine Oxidase (AOC3) Antibody (FITC)

20-abx336490
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Membrane Primary Amine Oxidase (AOC3) Antibody (Biotin)

20-abx336491
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human primary hepatic carcinoma,PHC ELISA Kit

201-12-1673 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Porcine Myeloid differentiation primary response protein MyD88,

ELI-05540p 96 Tests
EUR 1113.6

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-48T 48T
EUR 346.8

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-96T 96T
EUR 559.2

Human 293, transformed primary embryonal kidney lysate

HCL-1210 100ug
EUR 255.6

Antigen-Antibody Pen For Chicken Primary antibodies

PEN-C5 1
EUR 242.4

Antigen-Antibody Pen For Goat Primary antibodies

PEN-G3 1
EUR 242.4

Antigen-Antibody Pen For Human Primary antibodies

PEN-H7 1
EUR 242.4

Antigen-Antibody Pen For Mouse Primary antibodies

PEN-M2 1
EUR 242.4

Antigen-Antibody Pen For Rabbit Primary antibodies

PEN-R1 1
EUR 242.4

Antigen-Antibody Pen For Sheep Primary antibodies

PEN-S4 1
EUR 242.4

Antigen-Antibody Pen For Hamster Primary antibodies

PEN-T8 1
EUR 242.4

Human primary hepatic carcinoma(PHC)ELISA Kit

QY-E03406 96T
EUR 433.2

Mouse Aoc3/ Membrane primary amine oxidase ELISA Kit

E0103Mo 1 Kit
EUR 685.2

Human Membrane primary amine oxidase(AOC3) ELISA kit

CSB-EL001855HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Membrane primary amine oxidase(AOC3) ELISA kit

1-CSB-EL001855HU
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Membrane primary amine oxidase(AOC3) ELISA kit

CSB-EL001855MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Membrane primary amine oxidase(AOC3) ELISA kit

1-CSB-EL001855MO
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Myeloid differentiation primary response protein MyD88 (MYD88)

1-CSB-EP859945HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Myeloid differentiation primary response protein MyD88(MYD88) expressed in E.coli

Mouse Aoc3(Membrane primary amine oxidase) ELISA Kit

EM0513 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml

ELISA kit for Mouse Membrane primary amine oxidase

EK2704 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Membrane primary amine oxidase

EK2705 96 tests
EUR 542.4
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

Mammary Dissociation System 5 (Epitheliall), Mouse primary tumor

4-20325 ea Ask for price

Mouse Breast PrimaCell: Normal Mammary Epithelial Primary Cells

2-82021 1 Kit Ask for price

Human Breast PrimaCell: Normal Mammary Epithelial Primary Cells

2-96023 1 Kit Ask for price

Human AOC3(Membrane primary amine oxidase ) ELISA Kit

EH0577 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Human AOC3/ Membrane primary amine oxidase ELISA Kit

E2737Hu 1 Kit
EUR 644.4

Myd88 ELISA Kit| Mouse Myeloid differentiation primary response

EF013284 96 Tests
EUR 826.8

Mouse Membrane primary amine oxidase, Aoc3 ELISA KIT

ELI-03528m 96 Tests
EUR 1038

Human Membrane primary amine oxidase, AOC3 ELISA KIT

ELI-03529h 96 Tests
EUR 988.8

Bovine Membrane primary amine oxidase, AOC3 ELISA KIT

ELI-03531b 96 Tests
EUR 1113.6

Human Myeloid differentiation primary response protein MyD88, MY

ELI-05535h 96 Tests
EUR 988.8

Thus, the culture configuration shows the predicted in vitro platform for defining the profiles of glucose and lipid metabolism and screening of therapeutic agents for metabolic disorders such as diabetes and obesity.