CYP3A4 induction is an important cause of drug-drug interactions, making early identification of drug candidates with the obligations CYP3A4 induction in drug development prerequisites. Here, we present a 3D spheroid cultures of primary human hepatocytes (PHH) as CYP3A4 induction of new screening models.

Screening of 25 drugs (12 known inducers of CYP3A4 in vivo and 13 negative control) at physiologically relevant concentrations revealed 100% sensitivity and 100% specificity system. Three of inducers of CYP3A4 in vivo induction of CYP3A4 displayed capacity is much higher in comparison with the 3D spherical culture in 2D monolayer culture. Among them, we identify AZD1208, PIM kinase inhibitor in Phase I development stopped because of unexpected autoinduction CYP3A4, CYP3A4 inducer as the only active in 3D spheroids but not in 2D monolayer culture.

Gene knockdown experiments revealed that AZD1208 require PXR to induce CYP3A4. Rifampicin require PXR solely to induce CYP3A4 and CYP2B6, while phenobarbital-mediated induction of CYPs is not indicative of the absolute dependence on both PXR or CAR demonstrated its ability to switch the activation of nuclear receptors. Mechanistic Study of AZD1208 to find involvement of MAPK / ERK pathway in induction of CYP3A4-sensitive culture format used, as revealed by the inhibition of ERK1 / 2 phosphorylation Tyr204 and sensitivity to EGF pressure. Accordingly, we also identified lapatinib, a dual EGFR / HER2 inhibitor, such as CYP3A4 inducer active just another round in 3D culture.

Our findings offer insight into the pathways involved in the induction of CYP3A4 and suggest spheroids PHH for preclinical screening of CYP3A4 induction.

Glucose and lipid metabolism screening models of hepatocyte spheroids after culture by injecting fiber fragments.

With the increase in obesity, diabetes and other metabolic diseases, in vitro liver cell and tissue models play an important role in the identification of active pharmaceutical ingredients. Up to now three-dimensional (3D) models rarely focuses on the culture of hepatic glucose and lipid metabolism.

In addition, primary human liver cells suffer from limited availability and differences among donors to build the model reproduced. Thus, in this study, the most available human liver cancer cells (HepG2), and primary hepatocytes from rat (RPH) proposed to build a 3D spheroids using fiber fragments graft syringe with galactose (GSF) as a substrate. RPH and spheroids showed HepG2 cells and cell fragments strong-fiber interaction to promote cell survival, albumin and urea synthesis.

Compared with HepG2 spheroids, spheroids RPH demonstrate strong abilities in terms of consumption of glucose metabolism of glucose, glycogen intracellular content, the level of glucose in gluconeogenesis and sensitivity to the hormone modulators such as insulin and glucagon. On the other hand, HepG2 spheroids displays a strong ability of lipid metabolism in produce significantly higher levels of total cholesterol and triglycerides.

Compared with those who did not fragment the fiber, the GSF-supported 3D culture establish an effective model for in vitro glucose (RPH spheroids) and lipid metabolism (HepG2 spheroids). The model confirmed screening of each enzyme activity and gene expression and showed significantly higher sensitivity and clinically relevant response to hypoglycemic and lipid-lowering drugs.

Human Hepatocytes
HC4230	Neuromics	500,000 Cells	EUR 826.00

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat
4-20302	CHI Scientific	ea	Ask for price

Anti-Hepatocytes antibody
STJ16100176	St John's Laboratory	100 µg	EUR 389.00

Liver Dissociation System 4 (Hepatocytes, rat), Rat
4-20304	CHI Scientific	ea	Ask for price

Mouse Liver PrimaCell: Hepatocytes
2-82100	CHI Scientific	1 Kit	Ask for price

Human Liver PrimaCell: Hepatocytes
2-96121	CHI Scientific	1 Kit	Ask for price

Human Hepatocytes - Alcohol Addicted
HC4230AA	Neuromics	500,000 Cells	EUR 957.00

Human Hepatocytes - Opioid Addicted
HC4230OP	Neuromics	500000	EUR 957.00

Immortalized Human Hepatocytes - hTERT
T0058	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Human Hepatocytes - Ras
T0059	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Monkey Hepatocytes-SV40
T0073	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Mouse Hepatocytes - SV40
T0101	ABM	1x106 cells / 1.0 ml	Ask for price

Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol)
RAT-5	Alpha Diagnostics	1	EUR 1138.00

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium
9-25095	CHI Scientific	5 x 100 ml	Ask for price

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes
9-80322	CHI Scientific	1 x 100 ml	Ask for price

Immortalized Mouse Hepatocytes-Conditionally (ImHep)
T0099	ABM	1x106 cells / 1.0 ml	Ask for price

Liver Dissociation System 1 (Hepatocytes), Mouse
4-20301	CHI Scientific	ea	Ask for price

Immortalized Hamster Hepatocytes-SV40 T+t
T0071	ABM	1x106 cells / 1.0 ml	Ask for price

Immortalized Monkey Hepatocytes-SV40 T+t
T0074	ABM	1x106 cells / 1.0 ml	Ask for price

Rat of the Wistar strain, 22 organs, 66 cores (1.5mm), set 1
ART661	Pantomics	1	EUR 250.00
Description: Normal tissues of 22 major organs triplicated from 3 Wistar strain rats, set 1, non-overlapping with ART662

Rat of the Wistar strain, 22 organs, 66 cores (1.5mm), set 2
ART662	Pantomics	1	EUR 250.00
Description: Normal tissues of 22 major organs triplicated from 3 Wistar strain rats, set 2, non-overlapping with ART661

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat
4-20306	CHI Scientific	ea	Ask for price

TnI (Primary) Antibody
abx018056-100ug	Abbexa	100 ug	EUR 342.00
Shipped within 5-10 working days.

Primary Human Neurons
HNC001	Neuromics	300,000 Cyroperserved Cells	EUR 1223.00

Rat Primary hepatic carcinoma ELISA kit
E02P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit
E02P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit
E02P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat
4-20303	CHI Scientific	ea	Ask for price

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium
9-32100	CHI Scientific	5 x 100 ml	Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium
9-46121	CHI Scientific	5 x 100 ml	Ask for price

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes
9-80306	CHI Scientific	1 x 100 ml	Ask for price

Human Liver Tissue Preparation Buffer: Normal Hepatocytes
9-80314	CHI Scientific	1 x 100 ml	Ask for price

Antigen-Antibody Pen For Rat Primary antibodies
PEN-R10	Alpha Diagnostics	1	EUR 202.00

DB Primary Antibody diluent
DBD-125	DB Biotech	125 ml	EUR 150.00

DB Primary Antibody diluent
DBD-250	DB Biotech	250 ml	EUR 245.00

DB Primary Antibody diluent
DB-D-125	DB Biotech	125 ml	EUR 150.00

DB Primary Antibody diluent
DB-D-250	DB Biotech	250 ml	EUR 245.00

Primary Antibody Dropper Vial
PAV015	ScyTek Laboratories	1 ea.	EUR 53.00

Rat Membrane primary amine oxidase(AOC3) ELISA kit
CSB-EL001855RA-24T	Cusabio	1 plate of 24 wells	EUR 165.00
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Membrane primary amine oxidase(AOC3) ELISA kit
1-CSB-EL001855RA	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Breast PrimaCell: Normal Mammary Epithelial Primary Cells
2-82522	CHI Scientific	1 Kit	Ask for price

Rat Aoc3/ Membrane primary amine oxidase ELISA Kit
E0075Ra	Sunlong	1 Kit	EUR 571.00

Rat Aoc3(Membrane primary amine oxidase) ELISA Kit
ER0434	FN Test	96T	EUR 567.60
Detection range: 0.78-50 ng/ml Uniprot ID: O08590 Alias: Aoc3/VAP-1/HPAO/SSAO/Copper amine oxidase/HPAOSSAO/Semicarbazide-sensitive amine oxidase/VAP1/membrane primary amine oxidase/Vascular adhesion protein 1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml

Rat Myeloid differentiation primary response protein MyD88, Myd8
ELI-05538r	Lifescience Market	96 Tests	EUR 886.00

ELISA kit for Rat Membrane primary amine oxidase
EK2706	SAB	96 tests	EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

Primary Antibody Diluent (Tris, Green)
ATG-20000	ScyTek Laboratories	20 L	EUR 1177.00

Primary Antibody Diluent (Tris, Green)
ATG125	ScyTek Laboratories	125 ml	EUR 74.00

Primary Antibody Diluent (Tris, Green)
ATG500	ScyTek Laboratories	500 ml	EUR 101.00

Primary Antibody Diluent (Tris, Green)
ATG999	ScyTek Laboratories	1000 ml	EUR 124.00

Primary Antibody Diluent (Phosphate, Green)
APG125	ScyTek Laboratories	125 ml	EUR 74.00

Primary Antibody Diluent (Phosphate, Green)
APG500	ScyTek Laboratories	500 ml	EUR 101.00

Primary Antibody Diluent (Phosphate, Green)
APG999	ScyTek Laboratories	1000 ml	EUR 124.00

Primary Antibody Diluent (Phosphate, Green)
APG010	ScyTek Laboratories	10 L	EUR 671.00

Western blot Kit for Rat Primary Antibodies, Chemilum. Substrate
80203-Rt	Alpha Diagnostics	1 kit	EUR 651.00

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)
9-26095	CHI Scientific	1 Set	Ask for price

Membrane Primary Amine Oxidase (AOC3) Antibody
20-abx333876	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Myeloid Differentiation Primary Response 88 Protein
20-abx261025	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody
abx033988-400ul	Abbexa	400 ul	EUR 523.00
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody
abx033988-80l	Abbexa	80 µl	EUR 286.00
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody
20-abx001627	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

Western Blot Primary Antibody Diluent Buffer
abx090689-100ml	Abbexa	100 ml	EUR 182.00
Shipped within 5-10 working days.

Myeloid Differentiation Primary Response 88 Antibody
20-abx137458	Abbexa	EUR 704.00 EUR 328.00 EUR 230.00	100 ug 20 ug 5 ug
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody
20-abx110946	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

Human Primary hepatic carcinoma ELISA kit
E01P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit
E01P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit
E01P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit
E07P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit
E07P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit
E07P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit
E04P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit
E04P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit
E04P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit
E06P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit
E06P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit
E06P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit
E03P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit
E03P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit
E03P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit
E08P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit
E08P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit
E08P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Breast PrimaCell: Normal Mammary Epithelial Primary Cells Growth Medium
9-25022	CHI Scientific	5 x 100 ml	Ask for price

Rat Breast Tissue Preparation Buffer: Normal Mammary Epithelial Primary Cells
9-80229	CHI Scientific	1 x 100 ml	Ask for price

Rat Myd88/ Myeloid differentiation primary response protein MyD88 ELISA Kit
E0652Ra	Sunlong	1 Kit	EUR 571.00

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit
E02M0411-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit
E02M0411-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Myeloid differentiation primary response protein MyD88(MYD88) ELISA kit
E02M0411-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Myeloid differentiation primary response protein MyD88(MYD88) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Aoc3 ELISA Kit| Rat Membrane primary amine oxidase ELISA Kit
EF017277	Lifescience Market	96 Tests	EUR 689.00

Membrane Primary Amine Oxidase (AOC3) Antibody (HRP)
20-abx336489	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody (FITC)
20-abx336490	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Membrane Primary Amine Oxidase (AOC3) Antibody (Biotin)
20-abx336491	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Human primary hepatic carcinoma,PHC ELISA Kit
201-12-1673	SunredBio	96 tests	EUR 440.00
This primary hepatic carcinoma ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Antigen-Antibody Pen For Chicken Primary antibodies
PEN-C5	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Goat Primary antibodies
PEN-G3	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Human Primary antibodies
PEN-H7	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Mouse Primary antibodies
PEN-M2	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Rabbit Primary antibodies
PEN-R1	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Sheep Primary antibodies
PEN-S4	Alpha Diagnostics	1	EUR 202.00

Antigen-Antibody Pen For Hamster Primary antibodies
PEN-T8	Alpha Diagnostics	1	EUR 202.00

Human 293, transformed primary embryonal kidney lysate
HCL-1210	Alpha Diagnostics	100ug	EUR 213.00

Human primary hepatic carcinoma(PHC)ELISA Kit
GA-E1689HM-48T	GenAsia Biotech	48T	EUR 289.00

Human primary hepatic carcinoma(PHC)ELISA Kit
GA-E1689HM-96T	GenAsia Biotech	96T	EUR 466.00

Porcine Myeloid differentiation primary response protein MyD88,
ELI-05540p	Lifescience Market	96 Tests	EUR 928.00

Guinea pig Primary hepatic carcinoma ELISA kit
E05P0656-192T	B-Gene	192 tests	EUR 1270.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit
E05P0656-48	B-Gene	1 plate of 48 wells	EUR 520.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit
E05P0656-96	B-Gene	1 plate of 96 wells	EUR 685.00
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human primary hepatic carcinoma(PHC)ELISA Kit
QY-E03406	Qayee Biotechnology	96T	EUR 361.00

Human Myeloid differentiation primary response protein MyD88 (MYD88)
1-CSB-EP859945HU	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 37.2 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Myeloid differentiation primary response protein MyD88(MYD88) expressed in E.coli

Human Membrane primary amine oxidase(AOC3) ELISA kit
CSB-EL001855HU-24T	Cusabio	1 plate of 24 wells	EUR 165.00
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Membrane primary amine oxidase(AOC3) ELISA kit
1-CSB-EL001855HU	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Membrane primary amine oxidase(AOC3) ELISA kit
CSB-EL001855MO-24T	Cusabio	1 plate of 24 wells	EUR 165.00
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Membrane primary amine oxidase (AOC3) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Membrane primary amine oxidase(AOC3) ELISA kit
1-CSB-EL001855MO	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Membrane primary amine oxidase(AOC3) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Breast PrimaCell: Normal Mammary Epithelial Primary Cells
2-82021	CHI Scientific	1 Kit	Ask for price

Human Breast PrimaCell: Normal Mammary Epithelial Primary Cells
2-96023	CHI Scientific	1 Kit	Ask for price

Mammary Dissociation System 5 (Epitheliall), Mouse primary tumor
4-20325	CHI Scientific	ea	Ask for price

Mouse Aoc3/ Membrane primary amine oxidase ELISA Kit
E0103Mo	Sunlong	1 Kit	EUR 571.00

Antigen-Antibody Pen For G. Pig Primary antibodies
PEN-P6	Alpha Diagnostics	1	EUR 202.00

Mouse Aoc3(Membrane primary amine oxidase) ELISA Kit
EM0513	FN Test	96T	EUR 567.60
Detection range: 31.2-2000 pg/ml Uniprot ID: O70423 Alias: Aoc3/AOC3/VAP-1/HPAO/SSAO/Copper amine oxidase/HPAOSSAO/Semicarbazide-sensitive amine oxidase/VAP1/membrane primary amine oxidase/Vascular adhesion protein 1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml

Human AOC3/ Membrane primary amine oxidase ELISA Kit
E2737Hu	Sunlong	1 Kit	EUR 537.00

Myd88 ELISA Kit| Mouse Myeloid differentiation primary response
EF013284	Lifescience Market	96 Tests	EUR 689.00

Human AOC3(Membrane primary amine oxidase ) ELISA Kit
EH0577	FN Test	96T	EUR 524.10
Detection range: 1.56-100 ng/ml Uniprot ID: Q16853 Alias: AOC3/VAP-1/HPAO/SSAO/Copper amine oxidase/HPAOSSAO/Semicarbazide-sensitive amine oxidase/VAP1/membrane primary amine oxidase/Vascular adhesion protein 1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Mouse Membrane primary amine oxidase, Aoc3 ELISA KIT
ELI-03528m	Lifescience Market	96 Tests	EUR 865.00

Human Membrane primary amine oxidase, AOC3 ELISA KIT
ELI-03529h	Lifescience Market	96 Tests	EUR 824.00

Bovine Membrane primary amine oxidase, AOC3 ELISA KIT
ELI-03531b	Lifescience Market	96 Tests	EUR 928.00

Human Myeloid differentiation primary response protein MyD88, MY
ELI-05535h	Lifescience Market	96 Tests	EUR 824.00

Bovine Myeloid differentiation primary response protein MyD88, M
ELI-05536b	Lifescience Market	96 Tests	EUR 928.00

ELISA kit for Mouse Membrane primary amine oxidase
EK2704	SAB	96 tests	EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Membrane primary amine oxidase
EK2705	SAB	96 tests	EUR 452.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Membrane primary amine oxidase in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)
9-33100	CHI Scientific	1 Set	Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)
9-47121	CHI Scientific	1 Set	Ask for price

Western blot Kit for Rabbit Primary Antibodies, Chemilum. Substrate
80200-Rb	Alpha Diagnostics	1 kit	EUR 651.00

Western blot Kit for Goat Primary Antibodies, Chemilum. Substrate
80201-Gt	Alpha Diagnostics	1 kit	EUR 651.00

Western blot Kit for Mouse Primary Antibodies, Chemilum. Substrate
80202-Mo	Alpha Diagnostics	1 kit	EUR 651.00

Thus, the culture configuration shows the predicted in vitro platform for defining the profiles of glucose and lipid metabolism and screening of therapeutic agents for metabolic disorders such as diabetes and obesity.