Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.

CYP3A4 induction is an important cause of drug-drug interactions, making early identification of drug candidates with the obligations CYP3A4 induction in drug development prerequisites. Here, we present a 3D spheroid cultures of primary human hepatocytes (PHH) as CYP3A4 induction of new screening models.

Screening of 25 drugs (12 known inducers of CYP3A4 in vivo and 13 negative control) at physiologically relevant concentrations revealed 100% sensitivity and 100% specificity system. Three of inducers of CYP3A4 in vivo induction of CYP3A4 displayed capacity is much higher in comparison with the 3D spherical culture in 2D monolayer culture. Among them, we identify AZD1208, PIM kinase inhibitor in Phase I development stopped because of unexpected autoinduction CYP3A4, CYP3A4 inducer as the only active in 3D spheroids but not in 2D monolayer culture.

Gene knockdown experiments revealed that AZD1208 require PXR to induce CYP3A4. Rifampicin require PXR solely to induce CYP3A4 and CYP2B6, while phenobarbital-mediated induction of CYPs is not indicative of the absolute dependence on both PXR or CAR demonstrated its ability to switch the activation of nuclear receptors. Mechanistic Study of AZD1208 to find involvement of MAPK / ERK pathway in induction of CYP3A4-sensitive culture format used, as revealed by the inhibition of ERK1 / 2 phosphorylation Tyr204 and sensitivity to EGF pressure. Accordingly, we also identified lapatinib, a dual EGFR / HER2 inhibitor, such as CYP3A4 inducer active just another round in 3D culture.

Our findings offer insight into the pathways involved in the induction of CYP3A4 and suggest spheroids PHH for preclinical screening of CYP3A4 induction.

Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.
Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes.

Glucose and lipid metabolism screening models of hepatocyte spheroids after culture by injecting fiber fragments.

With the increase in obesity, diabetes and other metabolic diseases, in vitro liver cell and tissue models play an important role in the identification of active pharmaceutical ingredients. Up to now three-dimensional (3D) models rarely focuses on the culture of hepatic glucose and lipid metabolism.

In addition, primary human liver cells suffer from limited availability and differences among donors to build the model reproduced. Thus, in this study, the most available human liver cancer cells (HepG2), and primary hepatocytes from rat (RPH) proposed to build a 3D spheroids using fiber fragments graft syringe with galactose (GSF) as a substrate. RPH and spheroids showed HepG2 cells and cell fragments strong-fiber interaction to promote cell survival, albumin and urea synthesis.

Compared with HepG2 spheroids, spheroids RPH demonstrate strong abilities in terms of consumption of glucose metabolism of glucose, glycogen intracellular content, the level of glucose in gluconeogenesis and sensitivity to the hormone modulators such as insulin and glucagon. On the other hand, HepG2 spheroids displays a strong ability of lipid metabolism in produce significantly higher levels of total cholesterol and triglycerides.

Compared with those who did not fragment the fiber, the GSF-supported 3D culture establish an effective model for in vitro glucose (RPH spheroids) and lipid metabolism (HepG2 spheroids). The model confirmed screening of each enzyme activity and gene expression and showed significantly higher sensitivity and clinically relevant response to hypoglycemic and lipid-lowering drugs.

Normal Human Primary Plateable Hepatocytes

T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes

T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes

T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) hepatocytes, Plateable

T0112 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million

T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium

9-25095 5 x 100 ml Ask for price

Rat Hepatocytes

ABC-TC4136 1 vial Ask for price
Description: Rat Hepatocytes (RH) are isolated from adult rat livers. They are cryopreserved at the end of primary cell isolation.

Rat Plateable Hepatocytes

ABC-TC4024 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat

4-20302 ea Ask for price

Human Hepatocytes

ABC-TC3646 1 vial Ask for price
Description: The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell transplantation and clinical liver support systems. In appropriate culture condition, cultured human hepatocytes proliferate and maintain differentiated hepatocyte function such as the synthesis of serum proteins. HH from Gentaur Research Laboratories are isolated from human liver. HH are cryopreserved immediately after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HH are characterized by immunofluorescent method with antibodies to albumin, cytokeratin-18 and vimentin. HH are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HH is not recommended for expanding or long term cultures since the cells do not proliferate in culture.

Mouse Hepatocytes

ABC-TC3928 1 vial Ask for price
Description: Our High Quality Mouse Hepatocytes have been isolated from mouse livers after liver perfusion and low-speed differential centrifugation. The hepatocytes are cryoperserved immediately after the experimental process and delivered frozen.

Human Hepatocytes

HC4230 500,000 Cells
EUR 991.2

Human Hepatocytes

CSC-C1495 One Frozen vial Ask for price

Human Hepatocytes

ALHE33 1ml frozen Vial
EUR 620

Immortalized Rat Hepatocytes - SV40

T0078 1x106 cells / 1.0 ml
EUR 3950

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
Description: Rat Hepatocytes Suspension - Adult

Bovine Hepatocytes

ABC-TC3132 1 vial Ask for price
Description: Bovine hepatocytes, 4-week bovine

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Rabbit Liver Hepatocytes

ABC-TC4061 1 vial Ask for price
Description: Rabbit liver epithelial cells, 5-week rabbit

Plateable Mouse Hepatocytes

ABC-TC4023 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Immortalized human hepatocytes

ABI-TC3500 1 vial Ask for price
Description: The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.

Immortalized Monkey Hepatocytes

CSC-I2072Z One Frozen vial Ask for price

Conditionally Immortalized Rat Hepatocytes-SV40T

CSC-I2094Z One Frozen vial Ask for price

Plateable DOG (Beagle) Hepatocytes

ABC-TC4021 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Human iPSC-derived Hepatocytes

CSC-00863L One Frozen vial Ask for price

Human Hepatocytes - Opioid Addicted

HC4230OP 500000
EUR 1148.4

Human Hepatocytes - Opioid Addicted

HC4230OP-B each
EUR 805.5

Mouse Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-33100 1 Set Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-47121 1 Set Ask for price

Human Pooled Hepatocytes(Heps 10)

ABC-TC3458 1 vial Ask for price
Description: Human Pooled Primary Hepatocytes (Heps) provide an ideal culture model for drug testing and drug development.Heps 20 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 20 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Pooled Hepatocytes(Heps 20)

ABC-TC3459 1 vial Ask for price
Description: Human Pooled Primary Hepatocytes (HP2 Heps) provide an ideal culture model for drug testing and drug development. HP2 10 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 10 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Fresh Hepatocytes, Suspension

ABC-TC3432 1 vial Ask for price
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies.

Human Hepatocytes - Alcohol Addicted

HC4230AA 500,000 Cells
EUR 1148.4

Immortalized Human Hepatocytes - Ras

T0059 1x106 cells / 1.0 ml Ask for price

Human Hepatocytes - Alcohol Addicted

HC4230AA-B each
EUR 625.5

Immortalized Mouse Hepatocytes - SV40

T0101 1x106 cells / 1.0 ml
EUR 3950

Immortalized Human Hepatocytes - hTERT

T0058 1x106 cells / 1.0 ml Ask for price

Immortalize Human Hepatocytes-SV40

CSC-I9016L One Frozen vial Ask for price

Immortalized Hamster Hepatocytes (SV40)

T0072 1x10^6 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes-SV40

CSC-I2205Z One Frozen vial Ask for price

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml
EUR 3950

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80322 1 x 100 ml Ask for price

Human Hepatocytes-Single Donor, Male

ABC-TC3649 1 vial Ask for price
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s - single donor, male) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Sprague Dawley Rats Hepatocytes

ABI-TC047D 1 vial Ask for price
Description: Sprague Dawley rats hepatocytes conditionally Immortalised with temperature sensitive SV40 large T antigen.

HighQC™ Mouse Hepatocytes Stem Cell

ABC-SC0041 1 vial Ask for price
Description: Mouse Hepatocyte Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Human Hepatocytes-Single Donor, Female

ABC-TC3647 1 vial Ask for price
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Human Mature Hepatocytes, Non-Plateable

ABC-TC3893 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

HighQC™ Human IPSC-Derived Hepatocytes

ABC-SC2119 1 vial Ask for price
Description: These hepatocytes overcome the functionality, reproducibility, and availability limitations of existing primary cell and tumor-derived cell models by providing the following:Relevant hepatic functionality and phenotypic stabilityExpression of clinical targets that are relevant for liver and metabolic diseaseCompatibility with a wide range of 3D and microphysiological systemsQuality-controlled manufacturing and batch reproducibilityReady supply in a cryopreserved format

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml
EUR 3950

C57BL/6 Mouse Hepatocytes Suspension-Adult

ABC-TC3192 1 vial Ask for price
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult

Human Plateable Hepatocytes From Whole Livers

ABC-TC4022 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Immortalized Hamster Hepatocytes-SV40 T+t

T0071 1x106 cells / 1.0 ml
EUR 3950

Liver Dissociation System 1 (Hepatocytes), Mouse

4-20301 ea Ask for price

Human Hepatocytes-Single Donor, Male; Inducible

ABC-TC3650 1 vial Ask for price
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, male) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Human Hepatocytes - HPVE6/E7 and Myc

T0057 1x10^6 cells / 1.0 ml
EUR 350

Human Hepatocytes-Single Donor, Female; Inducible

ABC-TC3648 1 vial Ask for price
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Mouse Hepatocytes-Conditionally (ImHep)

T0099 1x106 cells / 1.0 ml
EUR 3950

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat

4-20306 ea Ask for price

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat

4-20303 ea Ask for price

Immortalized Human Hepatocytes - HPV E6/E7, hTERT & MycT58A

T0063 1x10^6 cells / 1.0 ml
EUR 350

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80306 1 x 100 ml Ask for price

Human Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80314 1 x 100 ml Ask for price

Primary Rat Hepatic Stellate Cells (HSC)

CSI071Ra01 5X10^5
EUR 880

Rat Primary hepatic carcinoma ELISA kit

E02P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E01A15814 96T
EUR 700
Description: ELISA

Rat Primary Hepatic Sinusoidal Endothelial Cells

T4900 5x10^5 cells / 1.0 ml Ask for price

Rat Wistar Serum

IRTWISER1000ML each
EUR 848
Description: Rat Wistar Serum

Rat Wistar Serum

IRTWISER100ML each
EUR 187
Description: Rat Wistar Serum

Rat Wistar Serum

IRTWISER10ML each
EUR 59
Description: Rat Wistar Serum

Rat Wistar Serum

IRTWISER500ML each
EUR 481
Description: Rat Wistar Serum

Rat Wistar Serum

IRTWISER50ML each
EUR 102
Description: Rat Wistar Serum

Rat Wistar Plasma

IRTWIPLAK2E1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK2E100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK2E10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK2E500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK2E50ML each
EUR 102
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK3E1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK3E100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK3E10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK3E500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLAK3E50ML each
EUR 102
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLALIH1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLALIH100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLALIH10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLALIH500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLALIH50ML each
EUR 102
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAC1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAC100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAC10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAC500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAC50ML each
EUR 102
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAE1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAE100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAE10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAE500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAE50ML each
EUR 102
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAH1000ML each
EUR 848
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAH100ML each
EUR 187
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAH10ML each
EUR 59
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAH500ML each
EUR 481
Description: Rat Wistar Plasma

Rat Wistar Plasma

IRTWIPLANAH50ML each
EUR 102
Description: Rat Wistar Plasma

Rat (Wistar strain)

RA601 each
EUR 270
Description: Rat (Wistar strain), Male, multiple organ normal tissue array, 2 cases/60 cores (core size 1.5mm)

Rat (Wistar strain)

RA621 each
EUR 270
Description: Rat (Wistar strain), Female, multiple organ normal tissue array, 2 cases/62 cores (core size 1.5mm)

Dog Primary hepatic carcinoma ELISA kit

E08P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E01A50717 96T
EUR 700
Description: ELISA

Goat Primary hepatic carcinoma ELISA kit

E06P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Primary hepatic carcinoma ELISA kit

E01A103011 96T
EUR 700
Description: ELISA

Mouse Primary hepatic carcinoma ELISA kit

E01A24561 96T
EUR 700
Description: ELISA

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Thus, the culture configuration shows the predicted in vitro platform for defining the profiles of glucose and lipid metabolism and screening of therapeutic agents for metabolic disorders such as diabetes and obesity.