Cleavage of cyclic AMP-responsive element-binding protein H aggravates myocardial hypoxia reperfusion injury in a hepatocyte-myocardial cell co-culture system.

This study aims to determine whether the proinflammatory cytokines have effects on myocardial cells (MC) and hepatocytes during myocardial ischemia to induce cyclic element-binding protein H (CREBH) cleavage AMP-responsive, enabling the acute phase response in the liver, and cause injury MCs.In superimposed on this research, transwell co-culture system hepatocyte-MC is used to investigate the relationship between the injury of hypoxia / reperfusion myocardial and CREBH cleavage.

MC and neonatal rat hepatocytes derived from the ventricles and heart Sprague Dawley rats each. MC inoculated into the lower chamber of the transwell chamber for 12 hours under hypoxia. The level of endoplasmic reticulum stress protein glucose-regulated protein 78 in MC, CREBH in hepatocytes, inflammatory factors (tumor necrosis factor-α and interleukin-6) levels, and cell viability is evaluated.

CREBH influence knockdown was also studied using short hairpin RNA specifically CREBH (Ad-CREBHi) .We found that proinflammatory cytokines affect MC and hepatocytes during myocardial ischemia to induce cleavage CREBH, activate the acute phase response in the liver, and cause injury superimposed on MCs. Expression of CREBH exacerbate the myocardial injury during myocardial ischemia.

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Development co-culture model of mouse primary hepatocytes and splenocytes to evaluate the genotoxicity of xenobiotics using medium-throughput Comet assay.

To date, only a limited number of toxicology studies have focused on the establishment and validation of in vitro genotoxicity screening system using primary hepatocytes, and the results of these studies have been inconsistent. Therefore, the aim of this study was to develop a model of effective co-culture of rat primary hepatocytes and splenocytes derived for screening chemicals for medium-throughput genotoxicity using the Comet assay.

Cleavage of cyclic AMP-responsive element-binding protein H aggravates myocardial hypoxia reperfusion injury in a hepatocyte-myocardial cell co-culture system.
Cleavage of cyclic AMP-responsive element-binding protein H aggravates myocardial hypoxia reperfusion injury in a hepatocyte-myocardial cell co-culture system.

Cocultured model is built and verified using known genotoxic and non-genotoxic compounds as positive and negative controls, respectively. Cytotoxicity was measured using Cell Counting Kit-8 and lactate dehydrogenase method. DNA damage was detected using both alkaline and formamidopyrimidine glikosilase DNA test (FPG) Comet. Compared with controls, DNA strand breaks and FPG-sensitive sites showed a significant concentration-dependent increase in group-treated genotoxic agents.

In contrast, DNA damage remains unchanged in groups of non-genotoxic-agent-treated. In addition, various types of DNA lesions lead to genotoxic agents depending on different times.

Primary Dog (Beagle) Hepatocytes, Suspension

T0117 5x10^5 cells / 1.0 ml
EUR 1375

Normal Human Primary Plateable Hepatocytes

T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes

T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes

T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) hepatocytes, Plateable

T0112 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million

T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium

9-25095 5 x 100 ml Ask for price

Rat Hepatocytes

ABC-TC4136 1 vial Ask for price
Description: Rat Hepatocytes (RH) are isolated from adult rat livers. They are cryopreserved at the end of primary cell isolation.

Rat Plateable Hepatocytes

ABC-TC4024 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat

4-20302 ea Ask for price

Human Hepatocytes

HC4230 500,000 Cells
EUR 991.2

Human Hepatocytes

ABC-TC3646 1 vial Ask for price
Description: The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell transplantation and clinical liver support systems. In appropriate culture condition, cultured human hepatocytes proliferate and maintain differentiated hepatocyte function such as the synthesis of serum proteins. HH from Gentaur Research Laboratories are isolated from human liver. HH are cryopreserved immediately after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HH are characterized by immunofluorescent method with antibodies to albumin, cytokeratin-18 and vimentin. HH are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HH is not recommended for expanding or long term cultures since the cells do not proliferate in culture.

Mouse Hepatocytes

ABC-TC3928 1 vial Ask for price
Description: Our High Quality Mouse Hepatocytes have been isolated from mouse livers after liver perfusion and low-speed differential centrifugation. The hepatocytes are cryoperserved immediately after the experimental process and delivered frozen.

Immortalized Rat Hepatocytes - SV40

T0078 1x106 cells / 1.0 ml Ask for price

Bovine Hepatocytes

ABC-TC3132 1 vial Ask for price
Description: Bovine hepatocytes, 4-week bovine

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
Description: Rat Hepatocytes Suspension - Adult

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Rabbit Liver Hepatocytes

ABC-TC4061 1 vial Ask for price
Description: Rabbit liver epithelial cells, 5-week rabbit

Plateable Mouse Hepatocytes

ABC-TC4023 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Immortalized human hepatocytes

ABI-TC3500 1 vial Ask for price
Description: The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.

Plateable DOG (Beagle) Hepatocytes

ABC-TC4021 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Human Hepatocytes - Opioid Addicted

HC4230OP 500000
EUR 1148.4

Human Pooled Hepatocytes(Heps 10)

ABC-TC3458 1 vial Ask for price
Description: Human Pooled Primary Hepatocytes (Heps) provide an ideal culture model for drug testing and drug development.Heps 20 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 20 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Pooled Hepatocytes(Heps 20)

ABC-TC3459 1 vial Ask for price
Description: Human Pooled Primary Hepatocytes (HP2 Heps) provide an ideal culture model for drug testing and drug development. HP2 10 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 10 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-33100 1 Set Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-47121 1 Set Ask for price

Human Hepatocytes - Alcohol Addicted

HC4230AA 500,000 Cells
EUR 1148.4

Human Fresh Hepatocytes, Suspension

ABC-TC3432 1 vial Ask for price
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies.

Immortalized Human Hepatocytes - Ras

T0059 1x106 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes - SV40

T0101 1x106 cells / 1.0 ml Ask for price

Immortalized Human Hepatocytes - hTERT

T0058 1x106 cells / 1.0 ml Ask for price

Immortalized Hamster Hepatocytes (SV40)

T0072 1x10^6 cells / 1.0 ml Ask for price

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml Ask for price

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80322 1 x 100 ml Ask for price

Human Hepatocytes-Single Donor, Male

ABC-TC3649 1 vial Ask for price
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s - single donor, male) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Sprague Dawley Rats Hepatocytes

ABI-TC047D 1 vial Ask for price
Description: Sprague Dawley rats hepatocytes conditionally Immortalised with temperature sensitive SV40 large T antigen.

HighQC™ Mouse Hepatocytes Stem Cell

ABC-SC0041 1 vial Ask for price
Description: Mouse Hepatocyte Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Human Hepatocytes-Single Donor, Female

ABC-TC3647 1 vial Ask for price
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Human Mature Hepatocytes, Non-Plateable

ABC-TC3893 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Rat Fischer 344 Plasma

IRTF344PLAACD100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAACD25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAACD500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAACD50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAASV100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAASV25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAASV500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAASV50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLACPD100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLACPD25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLACPD500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLACPD50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK2E100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK2E25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK2E500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK2E50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK3E100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK3E25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK3E500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLAK3E50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLALIH100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLALIH25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLALIH500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLALIH50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAC100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAC25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAC500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAC50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAE100ML each
EUR 2009
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAE25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAE500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAE50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAH100ML each
EUR 689
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAH25ML each
EUR 502
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAH500ML each
EUR 10042
Description: Rat Fischer 344 Plasma

Rat Fischer 344 Plasma

IRTF344PLANAH50ML each
EUR 1004
Description: Rat Fischer 344 Plasma

HighQC™ Human IPSC-Derived Hepatocytes

ABC-SC2119 1 vial Ask for price
Description: These hepatocytes overcome the functionality, reproducibility, and availability limitations of existing primary cell and tumor-derived cell models by providing the following:Relevant hepatic functionality and phenotypic stabilityExpression of clinical targets that are relevant for liver and metabolic diseaseCompatibility with a wide range of 3D and microphysiological systemsQuality-controlled manufacturing and batch reproducibilityReady supply in a cryopreserved format

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml Ask for price

C57BL/6 Mouse Hepatocytes Suspension-Adult

ABC-TC3192 1 vial Ask for price
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult

Human Plateable Hepatocytes From Whole Livers

ABC-TC4022 1 vial Ask for price
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Immortalized Hamster Hepatocytes-SV40 T+t

T0071 1x106 cells / 1.0 ml Ask for price

Liver Dissociation System 1 (Hepatocytes), Mouse

4-20301 ea Ask for price

Human Hepatocytes-Single Donor, Male; Inducible

ABC-TC3650 1 vial Ask for price
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, male) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Human Hepatocytes - HPVE6/E7 and Myc

T0057 1x10^6 cells / 1.0 ml
EUR 350

Human Hepatocytes-Single Donor, Female; Inducible

ABC-TC3648 1 vial Ask for price
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Mouse Hepatocytes-Conditionally (ImHep)

T0099 1x106 cells / 1.0 ml Ask for price

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat

4-20306 ea Ask for price

Fischer 344 (F344) Rat Astrocytes

ABC-TC3428 1 vial Ask for price
Description: Characterization: 1. Cell Activity; Recovery Viability ≥ 80%. 2. Cell Purity; - GFAP-positive cell percentage ≥ 70%. - β-tubulin III- or doublecortin- (Dcx-) positive cell percentage ≤ 10%. - GalC-positive cell percentage ≤ 10%.

Immortalized Human Hepatocytes - HPV E6/E7, hTERT & MycT58A

T0063 1x10^6 cells / 1.0 ml
EUR 350

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat

4-20303 ea Ask for price

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80306 1 x 100 ml Ask for price

Human Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80314 1 x 100 ml Ask for price

Immortalized Human Hepatocytes - HPV E6/E7, hTERT & MycT58A

T0054 1x10^6 cells / 1.0 ml
EUR 7950

Neosartorya fischer

Oneq-A570-OneqA570100D Oneq-A570-100D
EUR 515

Neosartorya fischer

Oneq-A570-OneqA570150D Oneq-A570-150D
EUR 594

Neosartorya fischer

Oneq-A570-OneqA57050D Oneq-A570-50D
EUR 413

Fischer 344 (F344) Fetal Rat Cortex Neurons

ABC-TC3426 1 vial Ask for price
Description: Characterization: 1. Cell Activity;- Recovery Viability ≥ 50%.- After approximately 2 days in culture, the cells will form clear dendrites and axons.- Cells can survive in culture for as long as 13-16 days.2. Cell Purity;- MAP2-positive cells ≥ 70%.- β-tubulin III-positive cells ≥ 70%.

Fischer 344 (F344) Fetal Rat Hippocampus Neurons

ABC-TC3427 1 vial Ask for price
Description: Characterization: 1. Cell Activity;- Recovery Viability ≥ 50%.- After approximately 2 days in culture, the cells will form clear dendrites and axons.- Cells can survive in culture for as long as 13-16 days.2. Cell Purity;- MAP2-positive cells ≥ 70%.- β-tubulin III-positive cells ≥ 70%.

Neosartorya fischer RT PCR kit

RTq-A570-100D 100T
EUR 860.4

Neosartorya fischer RT PCR kit

RTq-A570-150D 150T
EUR 969.6

Neosartorya fischer RT PCR kit

RTq-A570-50D 50T
EUR 717.6

Rat Primary hepatic carcinoma ELISA kit

E02P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E01A15814 96T
EUR 700
Description: ELISA

Neosartorya fischer One-Step PCR kit

Oneq-A570-100D 100T
EUR 1039.2

Neosartorya fischer One-Step PCR kit

Oneq-A570-150D 150T
EUR 1177.2

Neosartorya fischer One-Step PCR kit

Oneq-A570-50D 50T
EUR 861.6

O-ring set for Karl Fischer titrator

TIT1064 EACH
EUR 85.2

Rat Primary Hepatic Sinusoidal Endothelial Cells

T4900 5x10^5 cells / 1.0 ml Ask for price

Dog Primary hepatic carcinoma ELISA kit

E08P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E06P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Primary hepatic carcinoma ELISA kit

E01A50717 96T
EUR 700
Description: ELISA

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Primary hepatic carcinoma ELISA kit

E03P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Primary hepatic carcinoma ELISA kit

E01A103011 96T
EUR 700
Description: ELISA

Mouse Primary hepatic carcinoma ELISA kit

E01A24561 96T
EUR 700
Description: ELISA

Human Primary hepatic carcinoma ELISA kit

E01A7068 96T
EUR 700
Description: ELISA

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E04P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit

E09P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Primary hepatic carcinoma ELISA kit

E01A33283 96T
EUR 700
Description: ELISA

Bovine Primary hepatic carcinoma ELISA kit

E01A85584 96T
EUR 700
Description: ELISA

Monkey Primary hepatic carcinoma ELISA kit

E01A76864 96T
EUR 700
Description: ELISA

Canine Primary hepatic carcinoma ELISA kit

E01A68147 96T
EUR 700
Description: ELISA

Normal Human Primary Hepatic Kupffer Cells

T5549 1x10^6 cells / 1.0 ml
EUR 1115

Chicken Primary hepatic carcinoma ELISA kit

E01A94297 96T
EUR 700
Description: ELISA

Porcine Primary hepatic carcinoma ELISA kit

E01A59435 96T
EUR 700
Description: ELISA

Normal Human Primary Hepatic Stellate Cells

T5546 1x10^6 cells / 1.0 ml
EUR 1175

Human Primary Hepatic Non-Parenchymal Cells

T4061 5x10^5 cells / 1.0 ml Ask for price

Human primary hepatic carcinoma,PHC ELISA Kit

201-12-1673 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-48T 48T
EUR 346.8

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-96T 96T
EUR 559.2

Human primary hepatic carcinoma(PHC)ELISA Kit

QY-E03406 96T
EUR 433.2

Human primary hepatic carcinoma,PHC ELISA Kit

SL1444Hu 96 Tests
EUR 468

Human primary hepatic carcinoma,PHC ELISA Kit

YLA2711HU-48T 48T
EUR 435

Human primary hepatic carcinoma,PHC ELISA Kit

YLA2711HU-96T 96T
EUR 562.5

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Primary hepatic carcinoma ELISA kit

E05P0656-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea Pig Primary hepatic carcinoma ELISA kit

E01A42000 96T
EUR 700
Description: ELISA

Human Primary Hepatic Sinusoidal Endothelial Cells

T4220 5x10^5 cells / 1.0 ml
EUR 975

Mouse Primary Hepatic Sinusoidal Endothelial Cells

T4600 5x10^5 cells / 1.0 ml Ask for price

Rat Hepatocyte growth factor (Hgf)

1-CSB-RP084844R
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Hepatocyte growth factor(Hgf),partial expressed in E.coli

Rat Hepatocyte Growth Factor ELISA kit

E02H0208-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Hepatocyte Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Hepatocyte Growth Factor ELISA kit

E02H0208-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Hepatocyte Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Hepatocyte Growth Factor ELISA kit

E02H0208-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Hepatocyte Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Hepatocyte Growth Factor ELISA Kit

IRTHGFKT each
EUR 702
Description: Rat Hepatocyte Growth Factor ELISA Kit

Rat Hepatocyte Growth Factor ELISA kit

E01A13784 96T
EUR 700
Description: ELISA

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

abx195673-96tests 96 tests
EUR 990

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

20-abx190709
  • EUR 10131.60
  • EUR 5396.40
  • EUR 1243.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Hepatocyte Growth Factor (HGF)CLIA Kit

SCA047Ra-10x96wellstestplate 10x96-wells test plate
EUR 7342.85
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Hepatocyte Growth Factor (HGF) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Rat Hepatocyte Growth Factor (HGF)CLIA Kit

SCA047Ra-1x48wellstestplate 1x48-wells test plate
EUR 709.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Hepatocyte Growth Factor (HGF) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Rat Hepatocyte Growth Factor (HGF)CLIA Kit

SCA047Ra-1x96wellstestplate 1x96-wells test plate
EUR 962.69
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Hepatocyte Growth Factor (HGF) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Rat Hepatocyte Growth Factor (HGF)CLIA Kit

SCA047Ra-5x96wellstestplate 5x96-wells test plate
EUR 3972.1
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Hepatocyte Growth Factor (HGF) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

4-SCA047Ra
  • EUR 7404.00
  • EUR 3973.20
  • EUR 963.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Hepatocyte Growth Factor (HGF)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKN50852-48T 48T
EUR 450.45

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKN50852-5x96T 5x96T
EUR 3056.63

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKN50852-96T 96T
EUR 643.5

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKU09741-48T 48T
EUR 724.22

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKU09741-5x96T 5x96T
EUR 4914.35

Rat Hepatocyte Growth Factor (HGF) CLIA Kit

EKU09741-96T 96T
EUR 1034.6

Fish hepatocyte growth factor(HGF)ELISA Kit

CSB-E16527Fh-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Fish hepatocyte growth factor (HGF) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Fish hepatocyte growth factor(HGF)ELISA Kit

1-CSB-E16527Fh
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Fish hepatocyte growth factor(HGF) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Fish hepatocyte growth factor(HGF)ELISA Kit

EKC42344-48T 48T
EUR 604.03

Fish hepatocyte growth factor(HGF)ELISA Kit

EKC42344-5x96T 5x96T
EUR 4098.78

Fish hepatocyte growth factor(HGF)ELISA Kit

EKC42344-96T 96T
EUR 862.9

Rat Hepatocyte Growth Factor (HGF) ELISA Kit

abx255607-96tests 96 tests
EUR 764.4

Our results show that the tail DNA% showed both strands of DNA break and FPG-sensitive sites may be an effective marker for predicting chemical-induced DNA damage and oxidative DNA damage using a model cocultured hepatocytes and splenocytes. Collectively, these findings provide reliable experimental data for the establishment of in vitro genotoxicity screening methods.